systemsage

Composite Systems Age integrates the 11 mortality-associated physiological-system scores plus a DNAm chronological-age prediction through PCA and Cox elastic-net regression, then rescales the result to an age-like value.

Model weights retain the original authors' terms; the pyaging software license does not relicense them. These weights are restricted to research use under the authors' terms.

Predicts	multisystem biological age
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	PCA + elastic net regression
Year	2025

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["systemsage"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Sehgal, R., Markov, Y., Qin, C., et al. (2025). Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nature Aging, 5, 1880–1896.

https://doi.org/10.1038/s43587-025-00958-3